KPV (Lys-Pro-Val) is a tripeptide derived from the C-terminal fragment of alpha-melanocyte-stimulating hormone (α-MSH). CAS: 67727-97-3 | MW: 342.43 g/mol. Supplied at ≥98% purity for research into anti-inflammatory pathways and melanocortin receptor signalling.

Research Background

KPV represents the minimal active sequence of α-MSH (amino acids 11-13) that retains biological activity at melanocortin receptors while exhibiting improved stability and bioavailability compared to the full peptide. The tripeptide has been studied for its anti-inflammatory properties through modulation of the MC1R receptor pathway and inhibition of NF-κB signalling.

Mechanism of Action & Research Applications

• Anti-inflammatory activity: Inhibition of NF-κB activation and downstream pro-inflammatory cytokine production in cell models
• Melanocortin receptor modulation: Interaction with MC1R receptors involved in pigmentation and immune regulation
• Intestinal barrier research: Protection against inflammatory bowel disease models through maintenance of epithelial barrier function
• Dermatological research: Topical application studies for inflammatory skin conditions

Storage & Handling

• Long-term storage: -20°C, desiccated, protected from light
• Short-term storage: 2-8°C after reconstitution; use within 14-30 days
• Reconstitution: Bacteriostatic water for injection; swirl gently
• Stability: More stable than full-length α-MSH due to reduced peptide length

Related Research Compounds

Complementary melanocortin research: MT-2 Melanotan 2 10mg and other peptide modulators of inflammatory pathways.

For research use only. Not for human or animal consumption. Not a medicinal product.