MT-2 (Melanotan 2) is a synthetic cyclic heptapeptide analog of alpha-melanocyte-stimulating hormone (α-MSH). CAS: 121062-08-6 | MW: 1024.2 g/mol. Supplied at ≥98% purity for research into melanocortin receptor signaling, pigmentation pathways, and metabolic regulation.

Research Background

Melanotan 2 is a synthetic peptide developed as an analog of the naturally occurring α-MSH. Unlike the endogenous hormone, MT-2 exhibits enhanced stability and bioavailability while demonstrating affinity for multiple melanocortin receptor subtypes (MC1R, MC3R, MC4R, MC5R). The compound has been extensively studied in preclinical models for its effects on melanogenesis, energy homeostasis, and appetite regulation.

Mechanism of Action & Research Applications

• Melanocortin receptor agonism: Non-selective activation of MC1R (pigmentation), MC3R/MC4R (energy balance), and MC5R (exocrine function)
• Melanogenesis research: Studies on α-MSH pathway activation and melanin synthesis in melanocyte cultures
• Metabolic research: Investigation of MC4R-mediated effects on food intake, energy expenditure, and body weight in animal models
• Photoprotection studies: Research on UV-independent skin pigmentation mechanisms

Storage & Handling

• Long-term storage: -20°C, desiccated, protected from light
• Short-term storage: 2-8°C after reconstitution; use within 14-30 days
• Reconstitution: Bacteriostatic water for injection; swirl gently to avoid peptide degradation
• Stability: Lyophilized peptide stable at room temperature for 90 days; store refrigerated or frozen for extended stability

Related Research Compounds

Complementary melanocortin research: KPV 10mg and other peptide modulators of melanocortin pathways.

For research use only. Not for human or animal consumption. Not a medicinal product.