Human Growth Hormone (HGH, Somatotropin) is a 191-amino-acid single-chain polypeptide produced by anterior pituitary somatotrope cells. CAS: 12629-01-5 | MW: 22,124 Da. Supplied as recombinant HGH (rHGH) as a lyophilised protein at high purity for endocrinology, metabolism, and GH axis research.

Research Background

Human Growth Hormone has been studied for over 60 years, with recombinant production enabling broad research into the somatotropic axis, metabolic regulation, and body composition biology. The GH/IGF-1 axis is the central growth regulatory system and plays critical roles in adult metabolism including lipid mobilisation, protein synthesis, and glucose homeostasis. Age-related GH secretion decline (somatopause) has made GH axis research increasingly relevant to longevity biology.

Mechanism of Action & Research Applications

• Direct GH receptor (GHR) signalling: GH binds GHR dimers, activating JAK2/STAT5 and MAPK pathways, with direct metabolic effects including adipose tissue lipolysis and anti-insulin effects in muscle/liver
• Indirect IGF-1 axis stimulation: GH drives hepatic IGF-1 production; IGF-1 mediates most anabolic/growth-promoting effects through PI3K/AKT/mTOR signalling in muscle, bone, and other tissues

Applications: GH receptor pharmacology; IGF-1 axis biology; adipose lipolysis models; protein synthesis studies; bone metabolism research; downstream signalling cascade investigations.

Storage & Handling

• Long-term storage: -20°C (lyophilised stable 18-24 months)
• Short-term storage: 2-8°C after reconstitution; use within 14-30 days
• Reconstitution: Bacteriostatic water for injection; swirl gently – never shake vigorously
• CRITICAL: Never freeze reconstituted HGH – this denatures the protein irreversibly; store reconstituted only at 2-8°C
• Handling: Maintain cold chain; recombinant proteins are sensitive to agitation and temperature excursions

Related Research Compounds

Upstream GH regulation: CJC-1295 + Ipamorelin 10mg and Ipamorelin 5mg. Downstream effector: IGF-1 LR3 1mg.

For research use only. Not for human or animal consumption. Not a medicinal product.