Selank is a synthetic heptapeptide (Thr-Lys-Pro-Arg-Pro-Gly-Pro) derived from the endogenous immunomodulatory peptide tuftsin, developed by the Institute of Molecular Genetics, Russian Academy of Sciences. CAS: 129954-34-3 | MW: 751.86 g/mol. Supplied as a lyophilised powder at ≥99% purity (HPLC-verified) for neuroscience and psychopharmacology research.

Research Background

Selank was designed as a stabilised tuftsin analogue with enhanced CNS penetration and prolonged biological activity. The Pro-Gly-Pro C-terminal extension dramatically improves metabolic stability while extending pharmacological activity. Selank has achieved registered pharmaceutical status in Russia for anxiolytic applications, providing decades of well-documented preclinical research literature.

Mechanism of Action & Research Applications

• GABAergic modulation: Selank enhances GABAergic neurotransmission, producing anxiolytic-like behavioural profiles in animal models through a mechanism distinct from benzodiazepines
• BDNF upregulation: Increased BDNF expression in hippocampus and prefrontal cortex, shared with Semax but with distinct regional/temporal patterns
• Serotonin system interactions: Effects on serotonin reuptake and turnover in mood-associated brain regions
• Enkephalin metabolism: Potential inhibition of enkephalin-degrading enzymes, contributing to stress-attenuating effects in animal models

Storage & Handling

• Long-term storage: -20°C (lyophilised stable 24+ months)
• Short-term storage: 2-8°C for 3-4 weeks after reconstitution
• Reconstitution: Sterile water or physiological saline
• Handling: Aliquot upon reconstitution; protect from light and heat

Related Research Compounds

Frequently studied alongside Semax 11mg for comparative neuropharmacological studies. Researchers may also investigate 5-Amino-1MQ 10mg for cognitive biology through metabolic mechanisms.

Frequently Asked Questions

Q: What is Selank?

A: Selank is a synthetic heptapeptide (CAS 129954-34-3, MW 751.86 g/mol) derived from the immunopeptide tuftsin. Used in preclinical neuroscience research to study anxiolytic mechanisms, BDNF regulation, and GABAergic system modulation. For research use only.

Q: How is Selank typically used in research?

A: Reconstituted in sterile water or saline and administered in animal behavioural models or neural cell cultures to examine GABAergic neurotransmission, BDNF expression, and stress-response biology.

Q: What is the recommended storage for Selank?

A: -20°C lyophilised (24+ months). Reconstituted: 2-8°C for 3-4 weeks. Aliquot to avoid freeze-thaw degradation.

Q: What purity and form is Selank supplied in?

A: White lyophilised powder at ≥99% purity (HPLC-verified). 11mg per vial.

For research use only. Not for human or animal consumption. Not a medicinal product.