Semax is a synthetic heptapeptide analogue of the ACTH(4-7) fragment (Met-Glu-His-Phe-Pro-Gly-Pro), developed at the Institute of Molecular Genetics, Russian Academy of Sciences. CAS: 80714-61-0 | MW: 813.96 g/mol. Supplied as a lyophilised powder at ≥99% purity (HPLC-verified) for neuropharmacology and cognitive biology research.

Research Background

Semax was developed as a stable, biologically active ACTH fragment retaining neurotrophic properties without steroidogenic effects. It has achieved registered pharmaceutical status in Russia and has been studied extensively in neurological research contexts. The compound has a particularly strong literature in BDNF (Brain-Derived Neurotrophic Factor) upregulation, neuroprotection, and cognitive biology research.

Mechanism of Action & Research Applications

Key mechanisms investigated in Semax research include: BDNF upregulation in hippocampus and cortex; interactions with the melanocortin system through ACTH-related receptor binding; serotonergic neurotransmission modulation; neuroprotective properties in ischaemia models (reduced inflammatory mediators, decreased oxidative stress markers in neural tissue); and modulation of neurotrophic factor signalling cascades.

Half-Life & Stability

Semax has a short serum half-life due to peptidase activity. Intranasal delivery routes have been extensively studied in Russian clinical research for CNS delivery bypassing first-pass metabolism. The lyophilised form provides excellent pre-reconstitution stability.

Storage & Handling

• Long-term storage: -20°C (lyophilised, stable 24+ months)
• Short-term storage: 2-8°C for 3-4 weeks after reconstitution
• Reconstitution: Sterile water or physiological saline
• Handling: Aliquot upon reconstitution; protect from light and heat

Related Research Compounds

Semax is often studied alongside Selank 11mg in comparative neuropharmacological research. Researchers may also investigate 5-Amino-1MQ 10mg for NAD+/NNMT-related neurological research.

For research use only. Not for human or animal consumption. Not a medicinal product.