CJC-1295 + Ipamorelin 10mg combines two complementary GH-releasing compounds: CJC-1295 DAC (GHRH analogue with DAC modification, CAS 863288-34-0, MW ~3,647 g/mol) and Ipamorelin (selective GHSR-1a agonist, CAS 170851-70-4, MW 711.86 g/mol). Supplied as 5mg each in a white lyophilised powder at ≥99% purity (HPLC-verified).

Research Background

The scientific rationale for combining GHRH analogues with GHSR agonists is grounded in pituitary GH secretion physiology. GH release is governed by two primary hypothalamic inputs: GHRH (stimulatory) and somatostatin (inhibitory), with the ghrelin/GHSR system providing an additional stimulatory pathway. Engaging both the GHRH receptor (CJC-1295) and ghrelin receptor (Ipamorelin) simultaneously enables investigation of synergistic somatotrope stimulation.

Individual Component Profiles

CJC-1295 DAC: Modified GHRH analogue featuring Drug Affinity Complex (DAC) technology enabling covalent albumin binding, extending half-life from minutes (native GHRH) to several days. Valuable for studying sustained GH axis stimulation and downstream IGF-1 production.

Ipamorelin: Synthetic pentapeptide GHSR agonist with high receptor selectivity. Unlike GHRP-2 and GHRP-6, Ipamorelin demonstrates minimal cross-activation of cortisol, prolactin, or ACTH pathways – providing a cleaner pharmacological tool for isolated GH research.

Synergistic GH Secretion Mechanisms

Research documents additive to synergistic GH release when GHRH pathway agonists are combined with GHSR agonists. GHRH receptor activation drives cAMP/PKA signalling, while GHSR activation recruits Gq/IP3/calcium signalling – enhanced somatotrope stimulation through complementary parallel pathways.

Storage & Handling

• Long-term storage: -20°C (lyophilised powder stable for 24+ months)
• Short-term storage: 2-8°C for up to 4 weeks after reconstitution
• Reconstitution: Sterile bacteriostatic water; gentle swirling to dissolve
• Handling: Aliquot after reconstitution; avoid vortexing peptide solutions

Related Research Compounds

Researchers may also investigate Ipamorelin 5mg as a standalone control, HGH 10 IU for direct GH research, and IGF-1 LR3 1mg for downstream GH axis effector biology.

For research use only. Not for human or animal consumption. Not a medicinal product.