MOTS-C (Mitochondrial Open Reading Frame of the 12S rRNA Type-C) is a 16-amino-acid mitochondria-derived peptide (MDP) encoded within the 12S ribosomal RNA gene of the mitochondrial genome. CAS: 1627580-64-6 | MW: 2,174.6 Da. Supplied as lyophilised powder at ≥99% purity (HPLC-verified) for metabolic biology and longevity research.

Research Background

MOTS-C was first identified in 2015 by researchers at the University of Southern California, representing a landmark discovery establishing mitochondria as active hormonal signalling organelles – not merely passive energy generators. MOTS-C plasma levels decline with aging and in metabolic disease states. It is now understood as part of the mitochondria-nuclear communication network enabling organelle status to influence nuclear gene expression and systemic metabolism.

Mechanism of Action & Research Applications

• AMPK activation: Activates AMP-activated protein kinase, triggering metabolic adaptations: increased glucose uptake via GLUT4, enhanced fatty acid oxidation, and mitochondrial biogenesis via PGC-1a
• Folate cycle interaction: Regulates the folate cycle through AICAR interaction, linking mitochondrial signalling to one-carbon metabolism
• Insulin sensitivity: Animal models show improved insulin sensitivity in diet-induced obesity models
• Exercise-like effects: Plasma MOTS-C increases with exercise; exogenous administration produces exercise-adaptive metabolic signatures in sedentary animals
• Nuclear migration: Translocates from mitochondria to nucleus under metabolic stress, directly interacting with chromatin for gene regulation

Storage & Handling

• Long-term storage: -20°C (lyophilised stable 24+ months)
• Short-term storage: 2-8°C for up to 4 weeks after reconstitution
• Reconstitution: Sterile water or physiological saline; dissolves readily
• Handling: Standard peptide handling; aliquot; protect from light

Related Research Compounds

Mitochondrial biology panel: SS-31 10mg, NAD+ 500mg, and SLU-PP-332 5mg.

For research use only. Not for human or animal consumption. Not a medicinal product.