Kisspeptin is a neuropeptide encoded by the KISS1 gene, acting as the master endogenous regulator of the hypothalamic-pituitary-gonadal (HPG) axis through KISS1R (GPR54). Kisspeptin-10 (the active research form): CAS: 374897-41-3 | MW: 1,302.54 g/mol. Supplied as a lyophilised powder at ≥99% purity (HPLC-verified).

Research Background

The KISS1 gene was originally identified as a metastasis suppressor before its critical role in reproductive endocrinology was discovered in 2003. Loss-of-function mutations in KISS1 or KISS1R cause hypogonadotropic hypogonadism, establishing kisspeptin as indispensable for puberty onset and reproductive function. Since then, kisspeptin has been one of the most intensively studied neuropeptides in reproductive neuroendocrinology, with hundreds of publications characterising its role in GnRH neuron activation, seasonal reproductive rhythms, and metabolic-reproductive interactions.

Mechanism of Action & Research Applications

Kisspeptin neurons in the arcuate nucleus (GnRH pulse generator) and anteroventral periventricular nucleus make direct synaptic contact with GnRH neurons, providing the primary excitatory drive for pulsatile GnRH secretion. Research applications include: GnRH neuron activation studies; LH/FSH surge mechanism investigations; seasonal reproductive cycle studies in photoperiod-sensitive species; metabolic-reproductive axis research (kisspeptin neurons receive leptin signalling); and pubertal timing biology in developmental models.

Storage & Handling

• Long-term storage: -20°C (lyophilised stable 24+ months)
• Short-term storage: 2-8°C for up to 3 weeks after reconstitution
• Reconstitution: Sterile water; 0.1% acetic acid for improved initial solubility
• Handling: Aliquot to avoid freeze-thaw degradation; protect from light

Related Research Compounds

Researchers studying the HPG axis may also investigate HCG 5000 IU for downstream LH receptor signalling, and Tirzepatide 20mg for metabolic-hormonal interaction research.

For research use only. Not for human or animal consumption. Not a medicinal product.